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Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p

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In Faculty Publications

Title

Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p

Author(s)

Bale, Sherri J.
Dracopoli, Nicholas C.
Tucker, Margaret A.
Clark, Jr., Wallace H.
University of Pennsylvania, School of Medicine
Fraser, Mary C.
Stanger, Ben Z.
Green, Philip
Collaborative Research, Inc.
Donis-Keller, Helen
Housman, David E.

Description

We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone. An analysis of the cosegregation of the cutaneous malignant melanoma–dysplastic nevus trait with 26 polymorphic DNA markers on the short arm of chromosome 1 demonstrated the presence of a gene for susceptibility to melanoma. The gene was located between an anonymous DNA marker (D1S47) and the gene locus for pronatrodilatin, a commonly used reference gene (PND), in chromosome band 1p36. The odds were greater than 260,000:1 in favor of linkage at this location.

Date Published

2018-03-26

Files

  • Download HDK_Mapping.pdf

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Olin College of Engineering

An undergraduate engineering institution exploring innovative approaches to engineering education since its founding in 1997.

1000 Olin Way
Needham, MA 02492
781.292.2390